Having not started any of Solari's first seven games as Madrid coach, Isco came into a much rotated XI and found the net with a trademark strike.
Real Madrid trounced third division side Melilla 6-1 in a Copa del Rey round of 32 second leg on Thursday, completing a 10-1 aggregate victory.
Former regulars Isco and Marco Asensio starred in the Copa del Rey as they try to work their way back into Santi Solari's good graces.
Denis Suarez struck twice for Copa del Rey holders Barcelona as they thrashed Cultural Leonesa 4-1 to progress to the round of 16 5-1 on aggregate.
A second-half salvo from Atletico Madrid helped them sweep past Sant Andreu 4-0 on Wednesday and into the Copa del Rey round of 16 5-0 on aggregate.
Melilla have to use three different modes of transport to travel from Africa's north coast -- just to complete a cup tie they're already losing 4-0.
It was a night for Barcelona's youngsters as the La Liga leaders easily handled Cultural Leonesa in Copa del Rey action.
Ernesto Valverde picked a team of youngsters and squad players against Cultural Leonesa. Some responded to the call, others did not.
Holders Barcelona scraped a 1-0 win at third-tier Cultural Leonesa thanks to Clement Lenglet's late header in their Copa del Rey first-leg match.
Alvaro Odriozola's composed performance in Real Madrid's Copa del Rey win over Melilla suggested the potential for a larger role under Santi Solari.
Solari said the decisive win in his first game in temporary charge was "the fruit" of his players' positivity and commitment.
Santiago Solari got off to the perfect start as Real Madrid's interim coach when his side thrashed Melilla 4-0 in the Copa del Rey on Wednesday.
Gelson Martins netted his first goal for Atletico Madrid to help Diego Simeone's side scrape a 1-0 win at fourth-tier Sant Andreu on Tuesday.
Ernesto Valverde will hand opportunities to Barcelona's fringe players and youngsters when they travel to Cultural Leonesa in the Copa del Rey.
Real Madrid will travel to Spain's African enclave of Melilla to open the Copa del Rey, the first to include the top two tiers of Spanish clubs.
Curtain raiser has been a two-legged contest in the past but a tight schedule has led to a change this time around.
Barcelona celebrated their La Liga and Copa del Rey titles on Monday with a parade through the city's streets.
Real Madrid's Sergio Ramos says that his team lifting the Champions League would be worth "maybe a little more" than Barcelona's domestic double.
Sevilla midfielder Steven N'Zonzi has apologised for partying in Madrid hours after his side's 5-0 loss to Barcelona in the Copa del Rey final.
Barcelona captain Andres Iniesta says he will announce his future plans in the coming week after receiving a offer to play in China.
Barcelona captain Andres Iniesta scored a goal and rated 9/10 in the Copa del Rey final vs. Sevilla, in what was likely his last final with Barca.
Barcelona coach Ernesto Valverde said he'd have "given his arm" for the touch of Andres Iniesta after a Copa del Rey finals win against Sevilla.
Luis Suarez said Barcelona's Copa del Rey triumph sets the team up for a Copa and Liga double they would have accepted at the start of the season.