Mark Hughes has been a strong advocate of VAR but the Saints boss felt the technology had been used badly in Tuesday's League Cup loss to Leicester.
Leicester City's Nampalys Mendy fired home the decisive spot kick as they beat Southampton 6-5 on penalties after on Tuesday in the Carabao Cup.
Asked about De Bruyne's injury, Pep Guardiola told a news conference: "He's being checked by the doctors."
Leicester City's rescheduled fourth round Carabao Cup match against Southampton will take place on Nov. 27 at the King Power Stadium.
On-loan midfielder Mason Mount was one of Derby's most impressive performers in Carabao Cup defeat at parent club Chelsea.
Juan Foyth and Davinson Sanchez were too strong at the back as Tottenham downed West Ham to advance to the final eight in the Carabao Cup.
Tottenham will face Arsenal in the Carabao Cup quarterfinals at the Emirates on the week of Dec. 17, setting up two North London derbies that month.
Mauricio Pochettino is relishing the challenge of facing Arsenal and their new head coach Unai Emery in the quarterfinals of the Carabao Cup.
Arsenal boss Unai Emery defended Matteo Guendouzi after his red card against Blackpool saying the teenager is playing with the "spirit that I want."
Emile Smith Rowe was one of several stand-out youngsters as Arsenal saw out a nervy win against Blackpool in the Carabao Cup.
Petr Cech will be back in goal for Arsenal's Carabao Cup game against Blackpool on Wednesday, club manager Unai Emery has disclosed.
Mauricio Pochettino is happy Tottenham are returning to action so soon after defeat to Man City, but admits he'll rotate his squad against West Ham.
Frank Lampard's relationship with Chelsea was not behind the club's decision to allow Mason Mount and Fikayo Tomori to play against them for Derby.
Eden Hazard will not feature for Chelsea against Derby County, while Pedro and Olivier Giroud are also doubts.
Tottenham visit West Ham in the Carabao Cup on Wednesday night before traveling to Wolves on Saturday and facing PSV next Tuesday.
Chelsea face Derby, who Mason Mount and Fikayo Tomori, in the Carabao Cup fourth round and will allow the pair to play at Stamford Bridge.
Bernard was solid in his first start for Everton but the club seemed to again undervalue this competition in their Carabao Cup loss to Southampton.
Southampton knocked Everton out of the Carabao Cup 4-3 on penalties on Tuesday after the third round tie at Goodison Park had ended 1-1.
Mason Mount and Fikayo Tomori will not be allowed to play for Derby County against Chelsea when the two clubs meet in the Carabao Cup.
Ongoing work at Spurs' new stadium and the unavailability of Wembley on the weekend of Oct. 27-28 means they will now play on the Monday Oct. 29.
Frank Lampard is making a quick return to Chelsea as his Derby County side drew his former club from his playing days in the Carabao Cup fourth-roun
If even one Premier League point were dropped due to Liverpool progressing in the Carabao Cup, it would have been a disaster. It's good Chelsea won.
Mauricio Pochettino hailed the Tottenham Hotspur supporters who travelled to Milton Keynes after his side's Carabao Cup victory over Watford.