The three substitutes raised the tempo, changed the course of the match and dragged a spluttering home team from the brink of defeat to victory.
United resisted Southampton's pressure in Saturday's 1-0 victory at St Mary's.
Spurs have won their opening three away league games for the first time since 1991 after their first win at the London Stadium.
Chelsea striker Alvaro Morata insists that the club have shown they are in a fight for the Premier League title after dismantling Stoke 4-0.
The Magpies headed into the weekend fourth in the table after recording three successive top-flight victories for the first time since 2014.
Arsenal's failure to push harder for Jonny Evans in the summer of 2016 highlights one of Arsene Wenger's big shortcomings as a manager.
Mesut Ozil is fed up with life at the Emirates and is ready to swap Arsenal for Man United, while Everton are ready to return for Olivier Giroud.
Burnley boss Sean Dyche called for a review of diving protocols after Huddersfield's Rajiv van La Parra took an "unacceptable" tumble.
Arsene Wenger says losing Kieran Gibbs this summer hurt more than the departure of Alex Oxlade-Chamberlain.
Wayne Rooney's substitution in Everton's win was a tactical decision, Everton boss Ronald Koeman said, and not because of the elbow to his eye.