Tottenham vs. Arsenal is the weekend's big match, with both clubs in a real battle for a place in the top four.
Arsenal start the day in sixth, four points and a place below their bitter rivals, but a win at Wembley would be a massive shot in the arm for their Champions League hopes.
Antonio Conte is a man under pressure as Chelsea take on West Brom on Monday, and Manchester United travel to Newcastle as well as Liverpool facing Southampton.
Predict the outcome of all the weekend's action by voting in our polls.
Elsewhere, Manchester City face Leicester as they look to continue their charge to the Premier League title while Everton will hope to bounce back from their 5-1 hammering at Arsenal when they take on Crystal Palace at Goodison Park.
How will the latest round of matches go? Vote in the polls and have your say in the comments section below.