Barcelona re-open a five point lead over Atletico Madrid while Lionel Messi scored his 400th La Liga goal with a 3-0 win over Eibar.
2018 SeasonAll times ET
Goals from Gonzalo Escalante, Sergi Enrich and Kike ensured Santiago Solari's first match as permanent Real Madrid boss ended in defeat.
Atletico Madrid averted an embarrassing home defeat to minnows Eibar by drawing 1-1 thanks to a strike from teenage debutant Borja Garces.
Real Betis have announced the signing of Japan international Takashi Inui on a free transfer from La Liga rivals Eibar in interesting fashion.
Fernando Torres scored twice in his final appearance for Atletico Madrid in Sunday's 2-2 draw against Eibar.
Victory means Zinedine Zidane's side have won eight of their last nine matches in all competitions, but still trail Barcelona by 12 points.
Barcelona opened a 10-point lead in La Liga with a 2-0 win away to Eibar on Saturday.
Barcelona warmed up for their Champions League showdown with Chelsea by edging past Eibar, courtesy of Luis Suarez and Jordi Alba's goals.
Atletico Madrid were indebted to goalkeeper Jan Oblak as they closed the gap on leaders Barcelona to six points with a narrow 1-0 win at Eibar.
Valencia have loaned winger Fabian Orellana to fellow La Liga side Eibar until the end of the season, subject to a medical.
Eibar left-back Jose Angel has criticised Casemiro's "tough-guy attitude," saying the Real Madrid midfielder's behaviour on Sunday was was "awful."
Marco Asensio had a hand in two goals as Real Madrid recorded their fourth successive La Liga win with a routine 3-0 success over Eibar.
Deadly blazes swept across the Galicia region earlier this week, killing at least three people.
Lionel Messi turned on the style once again with four goals as Barcelona maintained their 100 percent start in La Liga with a 6-1 win over Eibar.