After a short stint in charge between 1988 and 1990, Oscar Tabarez took over again in 2006 and has led the South American nation ever since.
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Hirving Lozano was one of the few bright spots in Mexico's 4-1 loss to Uruguay. Here are three quick takes from the game.
Luis Suarez scored twice and added an assist as Uruguay beat Mexico 4-1 in Houston on Friday.
Mexico returns to the pitch for the first time since the World Cup with a friendly against Uruguay. Here's what to watch for in Friday's friendly.
With El Tri playing Uruguay on Friday, we look at some notable names from the South American country who've made their mark in Mexico.
Edinson Cavani is being rested after only recently returning to full fitness following a hamstring injury sustained at the World Cup.
Uruguay stars Luis Suarez and Diego Godin were players who expressed FIFA's decision to take temporary control of the country's federation.
FIFA intervened to take control of Uruguayan soccer on Tuesday in a bid to ensure fair elections can be held for the association's president.
Luis Suarez and Edinson Cavani will make the trip to the United States for Uruguay's Sept. 7 friendly against Mexico.
The newly crowned World Cup winner had Uruguay flag draped over his shoulders in a post-game press conference after the World Cup final victory.
The World Cup made a star out of Kylian Mbappe but what about the under-the-radar talents hoping to impress in Russia? We pick out three that did.
Uruguay president Tabare Vazquez says it would be "an honour" to receive Antoine Griezmann to his official residence in Montevideo.
Arsenal's Lucas Torreira received a hero's welcome upon returning to his hometown in Uruguay following his performance at the World Cup.
England were fined 70,000 Swiss Francs ($70,585) and Uruguay were given a 50,000 Swiss Francs sanction for breaking media and marketing rules.
ESPN brings you the best of the numbers from Belgium's 2-1 win over Brazil in the quarterfinals of the World Cup.
France midfielder Antoine Griezmann said it was "normal not to celebrate" his goal that helped knock Uruguay out of the World Cup.
France are in the World Cup semifinals despite not really breaking a sweat. They can, and will, need to do better if they're to win it all.
Uruguay were chasing the game when Fernando Muslera let an Antoine Griezmann shot slip through his fingers. It cost La Celeste in their defeat.
Spanish goalkeeper Pepe Reina has slammed the balls being used at the World Cup after Fernando Muslera's error led to Uruguay's World Cup exit.
"I'm proud of my teammates -- they were lions," Godin said, as he and the Uruguay players came off the pitch in tears.
Antoine Griezmann turned in his best performance of the World Cup so far as France eased past Uruguay 2-0 to reach the semifinals.
France reached the World Cup semifinals after a straightforward win over Uruguay courtesy of goals from Raphael Varane and Antoine Griezmann.
France beat Uruguay at for the first time at the WC while extending their unbeaten streak when Griezmann scores. ESPN brings you the best numbers.