Nevada had five 40-plus-yard touchdowns. Daniel Brown returned an interception 42 yards, Mannix scored from 47 and 58 yards out, Jaxson Kincaide added a 73-yard grab and Romeo Doubs went 80 yards on a punt return.
It was the fifth-highest scoring output in Nevada's history and the most in its FBS era, which began in 1992.
Gangi was 16-of-26 passing for 342 yards and three TDs, and Mannix caught four passes for 132 yards. Doubs gave Nevada its first punt return touchdown since 2011.
Nevada scored 23 unanswered points for a 23-9 lead and it was 30-19 at halftime before the Wolf Pack took control with 42 straight points.
Touchdowns on six straight drives put Nevada ahead 58-19.
Ohio State coach Ryan Day will get a $487,000 bonus at the end of this month for his work leading the Buckeyes football team during Urban Meyer's suspension.
Episode 3 of "Beyond The Stripes" focuses on the story of Mark Fossati, the fun-and-football-loving Tiger LB returning this season. Stay for teammate Tom Johnson's advice on fixing a broken leg!
The first episode of the series "Beyond The Stripes" looks at the return of 2016 Bushnell Cup winner John Lovett, and what he means to the Tigers.
Highlights from Harvard's season-opening 36-14 win over San Diego at Harvard Stadium
The North Carolina Tar Heels football team is donating their per diem allotments, sports drinks and use of the team's equipment truck to Hurricane Florence relief efforts.
Vanderbilt coach Derek Mason apparently doesn't think much of Notre Dame coach Brian Kelly's comment that tight end Alize Mack "was getting cut [blocked] maliciously" during Saturday's game.