McDonald was 22 of 33 on Saturday and has passed for 1165 yards and 13 touchdowns with no interceptions this season. Fred Holly III had 17 carries for 100 yards and two scores and John Ursua had nine receptions for 133 yards and a TD.
McDonald hit Ursua for a 6-yard touchdown and Byrd for a 10-yard score on Hawaii's first two possessions to make it 14-0. Rice (1-2) trimmed its deficit to 36-29 when Shawn Stankavage hit Aaron Cephus for a 19-yard touchdown with 1:48 to play but Hawaii recovered the ensuing onside kick and, on the next play from scrimmage, Holly ran 46 yards for a TD to cap the scoring 13 seconds later.
Stankavage finished 20-of-31 passing for 299 yards and two touchdowns with one interception for the Owls. Emmanuel Esukpa had 17 carries for 104 yards and a score.
Northwestern starting running back Jeremy Larkin has been diagnosed with cervical stenosis, a narrowing in the upper part of the spine, and is retiring from football.
Virginia Tech quarterback Josh Jackson is out indefinitely with a fractured tibia.
Ohio State defensive end Nick Bosa, an All-American selection in 2017 and the Big Ten's reigning defensive lineman of the year, will remain out for a few more weeks, coach Urban Meyer said Monday.
With a month of games to evaluate, here are college football's most advantaged squads at the game's most important position.
Clemson freshman Trevor Lawrence, who looked dominant in a win over Georgia Tech on Saturday, has been named the Tigers' new starting quarterback.
The explosion of turnover trinkets, a rewind of all the crazy plays, intense UCF fans and a Colorado mascot's unfortunate T-shirt cannon malfunction.