The Panthers (5-2, 3-1 Conference USA) are off to their best start in school history. It was also their second straight win against the Thundering Herd and their first at Marshall (6-2, 3-1).
McGough was 14-of-18 passing, and Owens finished with seven catches for 114 yards. They capped back-to-back scoring drives late in the second half.
Napoleon Maxwell ran for 93 yards and a touchdown, and Alex Gardner added another 71 yards rushing and a score. Brad Muhammad's 12-yard interception return for a touchdown stretched the Panthers' lead to 35-7 midway through the third quarter.
Chase Litton threw for 363 yards and three touchdowns, including two TD passes in the fourth quarter for Marshall.
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